CellInsight™ CX7 LED Pro High Content Analysis Platform from Thermo Fisher Scientific

Product Specs
ItemCellInsight™ CX7 LED Pro High Content Analysis Platform
CompanyThermo Fisher Scientific
Price Get Pricing Get Quote for this Product
Catalog NumberCX7A1110
QuantityEA
ApplicationsCell Analysis, High Content Screening, Fluorescence
SoftwareThermo Scientific™ HCS Studio™ 3.0 Cell Analysis Software
TypeHigh Content Screening Platform
Absorbance / ExcitationMultiple filter sets included
Light SourceLED, solid-state 7-color light engine
DetectionLED-based fluorescence, brightfield illumination and confocal capabilities
Dimensions20 in x 32 in x 18 in (50.8 cm x 81.3 cm x 45.7 cm)
Weight68 kg (150 lb)

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Thermo Fisher Scientific

168 Third Avenue

Waltham, MA 02451

United States

Phone: 800-678-5599

Company Profile

Website: www.thermofisher.com

(1) Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB AccumulationInternational Journal of Molecular SciencesJune 29, 2023Marta Jorge-Oliva, Jan R. T. van Weering, Wiep ScheperHigh-Content Microscopy and Automated Analysis Primary neurons in 96-well plates were imaged on a CellInsight CX7 High-Content Screening (HCS) Platform (ThermoFisher) controlled by HCS Studio 2.0 Cell Analysis software (ThermoFisher) using a 20× air objective

(2) Vaccine-Acquired SARS-CoV-2 Immunity versus Infection-Acquired Immunity: A Comparison of Three COVID-19 VaccinesVaccinesDecember 15, 2022Samanovic MI, Oom AL, Cornelius AR, Gray-Gaillard SL, Karmacharya T, Tuen M, Wilson JP, Tasissa MF, Goins S, Herati RS, et al.(ThermoFisher, Waltham, MA, USA, A32728) along with DAPI (1.24 µg/mL), and visualized by microscopy with the CellInsight CX7 High-Content Screening (HCS) Platform (ThermoFisher, Waltham, MA, USA) and high-content software (HCS), or the BioTek Cytation 7 Cell Imaging Multi-Mode Reader

(3) Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathologyAlzheimer's research & therapyDecember 14, 2022Jorge-Oliva M, Smits JFM, Wiersma VI, Hoozemans JJM, Scheper W.units. High-content microscopy and automated analysis Primary neurons cultured in 96-well plates were imaged on a CellInsight CX7 High-Content Screening (HCS) Platform (ThermoFisher) controlled by HCS Studio Cell Analysis software (ThermoFisher). Widefield mode and a

(4) CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axisOncogeneNovember 1, 2022Mohanty S, Mohapatra P, Shriwas O, Ansari SA, Priyadarshini M, Priyadarsini S, Rath R, Sultania M, Das Majumdar SK, Swain RK, et al.Viability/Cytotoxicity Kit (Thermo Fisher Scientific Cat # L3224) and high content screening was performed using CellInsight CX7 High-Content Screening (HCS) Platform. The green fluorescence indicates the living cells and red fluorescence indicates dead cells. Images

(5) Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdBmBioOctober 26, 2022Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, Chih-Jung Kuo, Sean P. McDonough, Susan L. Fubini, Stephen M. Lipkin, et al.h. High-content analysis on cell phenotypes. Quantitative analysis of cell phenotypes was performed using the CellInsight CX7 high-content screening (HCS) platform (Thermo Fisher Scientific). The nuclei were stained using either Hoechst 33342 (Thermo Fisher Scientific)

(6) Robust immune responses after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2 experienced individualsmedRxivSeptember 19, 2022Marie I. Samanovic et al.and a goat α-mouse IgG AF647 secondary antibody along with DAPI and visualized by microscopy with the CellInsight CX7 High-Content Screening (HCS) Platform (ThermoFisher) and high-content software (HCS) (69). CXCL13 detection CXCL13 was detected using the

(7) Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxelScientific ReportsSeptember 19, 2022Riley Plett, Paul Mellor, Stephanie Kendall, S. Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah H. Anderson°C with 5% CO2. Images of each well of the 384-well plates were acquired using a Thermo Scientific™ CellInsight™ CX7 High Content Screening (HCS) Platform. Nine fields of view were captured using a 10× (0.4 NA) air objective lens. Images were analyzed using

(8) Neuron-specific translational control shift ensures proteostatic resilience during ER stressThe EMBO journalAugust 16, 2022Wolzak K, Nölle A, Farina M, Abbink TE, van der Knaap MS, Verhage M, Scheper W.images from cells cultured in black 96‐well culture plates (Greiner 655,090) were acquired using a CellInsight CX7 High‐Content Screening (HCS) Platform (Thermo Fisher Scientific) controlled by HCS Studio Cell Analysis software (Thermo Fisher Scientific).

(9) SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escapeLife Science AllianceJuly 1, 2022Tarun Mishra, Rishikesh Dalavi, Garima Joshi, Atul Kumar, Pankaj Pandey, Sanjeev Shukla, Ram K Mishra, Ajit Chandetemperature and washed thrice with PBS to remove PFA and taken for imaging using the Thermo Scientific CellInsight CX7 High-Content Screening (HCS) Platform. To calculate the effect of spike mutations on syncytium formation, five different fields were randomly

(10) Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2–experienced individualsScience Translational MedicineFebruary 9, 2022Marie I. Samanovic et al.AB_2633277) along with 4′,6-diamidino-2-phenylindole (DAPI) at 1:4,000 and visualized by microscopy with the CellInsight CX7 High-Content Screening (HCS) Platform (Thermo Fisher Scientific) and high-content software (HCS) (69). Cellular phenotyping Peripheral blood

(11) TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosisBritish Journal of CancerJanuary 1, 2022Jianyang Hu et al.(Jackson ImmunoResearch #111-605-003) for 1 h. The LSM880 (Zeiss) laser scanning microscope or Thermo Scientific CellInsight CX7 High-Content Screening (HCS) Platform was used to capture images. Immunohistochemistry (IHC) of clinical breast cancer samples IHC was performed

(12) Genetic variation of staphylococcal LukAB toxin determines receptor tropismNature microbiologyJune 1, 2021Perelman SS, James DBA, Boguslawski KM, Nelson CW, Ilmain JK, Zwack EE, Prescott RA, Mohamed A, Tam K, Chan R, et al.(1:8; Thermo Fisher Scientific, R37605) for 20 min at room temperature. Stained cells were imaged using CellInsight CX7 High-Content Screening (HCS) Platform (Thermofisher) with the 4x objective acquiring 9 fields per well to cover the entire 96-well. Images

(13) KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung CancerCancersApril 14, 2021Hill KS, McDowell A, McCorkle JR, Schuler E, Ellingson SR, Plattner R, Kolesar JM.H10292). Cells were imaged using the CellInsight CX7 High Content Analysis Platform (ThermoScientific: CX7A1110) and quantification of nuclear pH2AX signal was performed using the HCS Studio software (ThermoScientific).

(14) The Overexpression of Keratin 23 Promotes Migration of Ovarian Cancer via Epithelial-Mesenchymal TransitionBioMed Research InternationalNovember 1, 2020Meng Ren, Yan Gao, Qi Chen, Hongyu Zhao, Xiaoting Zhao, Wentao Yuetemperature. DAPI was used to stain the nuclear DNA. Imaging was performed using a Thermo Scientiﬁc™ CellInsight™ CX7 High Content Screening (HCS) Platform. 3. Results 3.1. KRT23 Overexpression in OC Tissues and Cell Lines. To explore the expression of KRT23

(15) In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface CulturesSLAS technologyJune 1, 2020Marescotti D, Bovard D, Morelli M, Sandoz A, Luettich K, Frentzel S, Peitsch M, Hoeng J.camera objective and eliminating interference from the plastic bottom. Images were acquired with the CellInsight CX7 High-Content Screening (HCS) Platform (Thermo Fisher Scientific) and analyzed with Studio software (Thermo Fisher Scientific) by using the Spot

(16) Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neuronsEuropean Journal of NeuroscienceMay 1, 2020John D. Graef et al.washed three times with PBST at room temperature and subjected to imaging with a 20× objective using CellInsight CX7 High‐Content Screening (HCS) Platform in wide‐field mode (Thermo Fisher Scientific). Images were analyzed using a modified “Neurite Detection

(17) Chaperone mediated detection of small molecule target binding in cellsNature communicationsJanuary 23, 2020Cho KF, Ma TP, Rose CM, Kirkpatrick DS, Yu K, Blake RA.Biotek EL406. Quantitative fluorescence imaging of the proteins of interest was carried out using a CellInsight CX7 High-Content Screening (HCS) Platform (Thermo Fisher Scientific). Fluorescence images of the samples were acquired in 2 channels: Channel

(18) Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathologyActa neuropathologicaDecember 1, 2019Wiersma VI, van Ziel AM, Vazquez-Sanchez S, Nölle A, Berenjeno-Correa E, Bonaterra-Pastra A, Clavaguera F, Tolnay M, Musters RJP, van Weering JRT, et al.1. Single focal plane images from neurons in 96-well plates were acquired using the 20 × objective a CellInsight CX7 High-Content Screening (HCS) Platform (ThermoFisher Scientific) controlled by HCS Studio Cell Analysis software (ThermoFisher Scientific).

(19) Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neuronsScientific ReportsDecember 1, 2019Anna Maria van Ziel, Pablo Largo-Barrientos, Kimberly Wolzak, Matthijs Verhage, Wiep Scheper(as described in the immunocytochemistry section). Neurons were imaged using a cellomics array scan (CellInsight CX7 High-Content Screening (HCS) Platform; ThermoFisher Scientific) with a 10x objective, 15 fields of view per well. Quantification was performed

(20) The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon responsePLoS PathogensNovember 4, 2019Leon Louis Seifert, Clara Si, Debjani Saha, Mohammad Sadic, Maren de Vries, Sarah Ballentine, Aaron Briley, Guojun Wang, Ana M. Valero-Jimenez, Adil Mohamed, Uwe Schaefer, Hong M. Moulton, Adolfo García-Sastre, Shashank Tripathi, Brad R. Rosenberg, Meike DittmannImageJ. Viral growth assays by microscopy and image analysis If not otherwise stated, we used the CellInsight CX7 High-Content Screening (HCS) Platform (Thermofisher) and high-content software (HCS) for microscopy and image analysis. For virus spread experiments,

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CellInsight CX7 High-Content Screening (HCS) Platform

CellInsight™ CX7 LED Pro High Content Analysis Platform from Thermo Fisher Scientific

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Thermo Fisher Scientific

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CellInsight™ CX7 LED Pro High Content Analysis Platform from Thermo Fisher Scientific

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